RESEARCH PROGRESS ON TETRAZOLE DERIVATIVES

Abstract

This review explores the latest developments in the synthesis of tetrazole derivatives, including mono-, 1,5H-, and 2,5H-substituted forms. Scientific study has recorded the diverse biological and clinical applications of these chemicals, which have attracted attention due to their demonstrated roles in antiviral, anti-tuberculosis, anticancer, antimalarial, and anti-inflammatory actions. While the distinctive structural features of 1,5H-disubstituted and 2,5H-disubstituted tetrazoles contribute to their distinct pharmacological profiles, the flexibility of mono-substituted tetrazoles highlights their potential across a range of therapeutic applications. The process of synthesizing these derivatives is essential to increasing their usefulness in drug development and presents encouraging opportunities for the creation of novel therapeutic agents. The important developments in tetrazole chemistry are highlighted in this study, along with their possible influence on the advancement of pharmaceutical innovation and biomedical research in the face of various medical issues.