RESEARCH PROGRESS ON TETRAZOLE DERIVATIVES

Abstract

This review explores the latest developments in the synthesis of tetrazole derivatives, including
mono-, 1,5H-, and 2,5H-substituted forms. Scientific study has recorded the diverse biological
and clinical applications of these chemicals, which have attracted attention due to their
demonstrated roles in antiviral, anti-tuberculosis, anticancer, antimalarial, and anti-inflammatory
actions. While the distinctive structural features of 1,5H-disubstituted and 2,5H-disubstituted
tetrazoles contribute to their distinct pharmacological profiles, the flexibility of mono-substituted
tetrazoles highlights their potential across a range of therapeutic applications. The process of
synthesizing these derivatives is essential to increasing their usefulness in drug development and
presents encouraging opportunities for the creation of novel therapeutic agents. The important
developments in tetrazole chemistry are highlighted in this study, along with their possible
influence on the advancement of pharmaceutical innovation and biomedical research in the face
of various medical issues.