Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research

Abstract

An exciting new direction in topical administration is the use of cationic nanocapsules. To improve the photostability, user compliance, and pharmacodynamic effectiveness of tretinoin (TTN), we built on a new formulation that relies on cationic nanocapsules. The nanoprecipitation process was used to create TTN nanocapsules in order to accomplish this. A Box-Behnken design was used with the help of Design-Expert software to statistically optimize the formulation variables. The cationic acrylic polymer weight (X1), oil volume (X2), and total transdermal N-terminal thickness (X3) were the three independent variables that were examined. As for the dependent variables, we chose particle size and encapsulation efficiency percentage (EE%).