Visible Spectrophotometric Determination of Bendamustine By Complex Formation

Abstract

A validate rapid, economical and sensitive visible spectrophotometric method has been developed for quantitative determination of bendamustine hydrochloride in bulk drug and formulation sampleswith no interference from the excipients or solvents of injectable solution. This method is validated for irinotecan with chromogenic reagent 2,2’-bipyridyl.The calibration curve is linear over a concentration range from 2-12µg/ml .The relative standard deviation (R.S.D) is less than 1% and average recovery is above 100.00 %.The proposed method is fast, sensitive, precise, accurate and efficient and can be used for analysis in quality control laboratories.