Formulation and Development of Rutin and Gallic Acid Loaded Herbal Gel for The Treatment of Psoriasis and Skin Disease

Abstract

Psoriasis is a chronic, non-contagious, autoimmune genetic disorder characterized by keratinocyte differentiation and dermo-epidermal inflammatory infiltration affecting upper back sacral region, scalp, nails and joints and may cause psoriatic arthritis, myopathy, enteropathy, spondylitic heart disease, malignancy or the AIDS. It appears first in 15 and 30 years age group. Histopathology of disease involves acanthosis, elongation and oedema of dermal papillae, absence of granular cell layer suprapapillary thining of stratum malpighii and prominent parakeratosis. Many drugs have been introduced in the market like clobetasol propionate, acitretin, methotrexate etc. but no single entity has proved to be beneficial to the patients. Though advancements have taken place in modern therapy it suffers from few shortcomings like no cure, treatment dissatisfaction and unavoidable drug interactions on long exposure.