Three-Component Zn(OAc)2-Catalyzed one pot synthesis of mono and disubstituted Pyrimidine Derivatives.

Abstract

The Zn(OAc)₂-catalyzed three-component coupling reaction using triethyl orthoformate (3 eq.), and ammonium acetate (2 eq.), to synthesis mono & disubstituted pyrimidine derivatives in single step. This method is successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives by using biodegradable,ecofriendly polychem@36 as solvent in ultrasound condition at 80⁰C giving good yield upto 80-90% .The reaction is completed in short period of time i.e. 1-3 hrs as compared to other reaction.