Three-Component Zn(OAc)2-Catalyzed one pot synthesis of mono and disubstituted Pyrimidine Derivatives.

Authors

  • Dr. Swanand Shrinivasrao Mukhedkar
  • Dr.Balaji Digambar Kokane
  • Jitendra Hanmantrao

Keywords:

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Abstract

The Zn(OAc)2-catalyzed three-component coupling reaction using triethyl orthoformate (3 eq.), and ammonium acetate (2 eq.), to synthesis mono & disubstituted pyrimidine derivatives in single step. This method is successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives by using biodegradable,ecofriendly polychem@36 as solvent in ultrasound condition at 800C giving good yield upto 80-90% .The reaction is completed in short period of time i.e. 1-3 hrs as compared to other reaction.

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Published

2024-04-08

How to Cite

Mukhedkar, D. S. S., Kokane, D. D., & Hanmantrao , J. (2024). Three-Component Zn(OAc)2-Catalyzed one pot synthesis of mono and disubstituted Pyrimidine Derivatives. Journal of Science & Technology (JST), 9(4), 1–7. Retrieved from https://jst.org.in/index.php/pub/article/view/43