Synthesis, Characterization and Antimicrobial Evaluation of a new Macrocyclic Ligand and Its Co (II), Ni (II,) Cu (II) and Zn (II)Complexes

Abstract

:Coordination complexes derived from macrocyclic ligand metal complexes of Co (II), Ni (II,) Cu (II) and Zn (II) have been synthesized. The Schiff base ligand was synthesized by condensation of 1-(5-bromo -2- hydroxyphenyl) -3- (furan -2-yl) propane -1,3-dione with o-phenylenediamine. The metal complexes ML (H2O)nare reported and characterised by conductivity, UV- visible, FTIR, H1NMR, TGA-DTA and XRD analysis. All the complexes were found to be non-electrolytic in nature. The ligand acts as a hexadentate and coordinates through four nitrogen atoms of azomethine groups. The antibacterial and antifungal activities of the ligand and its metal complexes, has been screened in vitro against Gentamycin, Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin and Griseofulvin used as standard drug. All these complexes show higher biological activities than standard drugs.