Significance of Povarov Reaction in Organic synthesis: An overview

Abstract

:The Povarov reaction has enabled and shaped the art and science of organic synthesis over the last few decades to an extent that has yet to be eclipsed by any other transformation in the current synthetic repertoire. With myriad applications of this magnificent Pericyclic reaction, often as a crucial element in elegant and programmed cascade sequences facilitating complex molecule construction, the Povarov cycloaddition has afforded numerous and unparalleled solutions to a diverse range of synthetic puzzles provided by nature in the form of natural products. Selected examples of the awesome power of the reaction he helped to discover are discussed in this review in the context of organic synthesis to illustrate its overall versatility and underscore its vast potential which has yet to be fully realized.