Hiptage benghlensis Leaf Extracts' Hypolipidemic Effect on High-Fat Diet-Induced Hyperlipidaemic Rats

Abstract

The goal of the current research was to assess the hypolipidemic effects of Hiptage benghalensis leaf aqueous extract (HBAE) and ethanolic extract (HBEE) utilizing an animal model of hyperlipidemia caused by a high-fat diet. Male albino wistar rats weighing between 120 and 150 grams were divided into six groups. Rats classified as hyperlipidemic (groups II, III, IV, V, VI, and VII) were fed a high-fat diet in order to induce hyperlipidemia, whereas normal rats (group I) were given a conventional laboratory diet along with 0.3% carboxy methyl cellulose (CMC). Group II, the hyperlipidaemic control group, was given 0.3% CMC (10 mL/kg/day). Group III, the standard group, was given gemfibrozil (50 mg/kg/day, p.o.). Groups IV and V, the HBAE groups, were given an aqueous extract of H. benghalensis (100 and 200 mg/kg/day, p.o.), and groups VI and VII, the HBEE groups, were given an ethanolic extract of H. benghalensis (100 and 200 mg/kg/day, p.o.), all of which were administered in conjunction with a high-fat diet for four weeks in a row. When compared to hyperlipidaemic rats (group II), the HBAE and HBEE treatments resulted in a substantial (p < 0.05) reduction in blood lipids (TC, TG, LDL, and VLDL) and rise in cardioprotective HDL. Phytochemical screening identified phytoconstituents that may be responsible for the hypolipidemic effects reported, including alkaloids, flavonoids, saponins, tannins, phenolic compounds, and steroids. According to the results of the current investigation, HBEE (200 mg/kg, p.o.) produced strong hypolipidemic effects.