Synthesis, Characterization & Antimicrobial activity of several Quinazolinone Schiff bases, 7-hydroxy-10,11-dihydroindeno[5,4- c]chromene-6(9H)-one & their Cu(II) complexes

Abstract

The aim of this study was to synthesize mixed ligand complexes of copper(II) with a coumarin derivative,(1=7-hydroxy-10,11-dihydroindeno[5,4-c]chromene-6(9H)-one), and six Quinazolinone Schiff base derivatives, 2a-2f and characterize their structure using various spectroscopic techniques, including elemental analysis, , IR spectra, 1H-NMR spectra, FAB mass spectra, magnetic measurement and thermal studies. In addition, the ligands, complexes, metal salt and control were tested in vitro for their biological activities against gram positive and gram negative micro organism. The results indicated that the metal complexes showed significantly higher activities compared to the free ligands and metal salt.