Supplementation of Vitamin D improves Insulin Resistance and Oxidative Stress in PCOS women. A Comprehensive Review

Abstract

The aim of the present review was to evaluate the effect of vitamin D (VD) supplementation (alone or co-supplementation) on insulin resistance and oxidative stress in VD deficient polycystic ovary syndrome (PCOS) subjects. Using PubMed, Google Scholar and Web of Science, we searched for publications in the last 10 years regarding the role of VD in PCOS students. It was found that the prevalence of VD deficiency was higher in PCOS subjects in comparison to control. We compared the effects of supplementation of VD in PCOS patients on insulin resistance (IR) value and oxidative stress markers (MDA). It was found that VD as a co-supplement could significantly decrease fasting glucose concentrations and the HOMAIR value. Further VD supplementation in patients with PCOS resulted in a significant improvement in high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA